In Mice, Cancer Drug Shows Effect on Alzheimer’s Symptoms THURSDAY Feb. 9, 2012 — The cancer drug bexarotene quickly eliminates Alzheimer’s disease-associated amyloid beta from the brain and reverses memory problems in mice, a new study finds.The results suggest that bexarotene could possibly help the approximately 5.4 million Americans with Alzheimer’s disease, according to the neuroscientists at Case Western Reserve University School of Medicine.However, while studies involving animals can be useful, they often fail to produce similar results in humans.Bexarotene is approved in the United States to treat skin problems caused by cutaneous T-cell lymphoma.The body’s inability to clear amyloid beta from the brain is a major factor in the development of Alzheimer’s disease, according to a university news release. Previous research showed that the main cholesterol carrier in the brain, apolipoprotein E (ApeE), plays an important role in clearing amyloid beta proteins.In this study, the researchers found that bexarotene increased ApoE expression, and the elevated levels of ApoE boosted clearance of amyloid beta from the brain
In Mice, Cancer Drug Shows Effect on Alzheimer's Symptoms …
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In Mice, Cancer Drug Shows Effect on Alzheimer's Symptoms …