An Introduction to Toxicogenomics

An Introduction to Toxicogenomics

An Introduction to Toxicogenomics
edited by Michael E. Burczynski

ISBN: 0849313341 | year 2003 | English
348pages | pdf | size: 10,60 Mb

Features:
Presents a clear introduction to expression profiling and large scale data analysis applicable to any field of research
Explains the complex clustering algorithms required for expression profiling analyses
Includes stunning images involved in microarray analysis of large-scale data sets
Provides additional information and cites specific examples that illustrate the principles of toxicogenomics
Describes toxicogenomic findings in two of the main model systems employed in toxicological research today
Equally explores concepts and applications in both mechanistic and predictive toxicogenomics
Gathering together leading authors and scientists at the forefront of the field, An Introduction to Toxicogenomics provides a comprehensive overview of this new discipline. With a focus on toxicology, it introduces the basic principles of microarray/oligonucleotide array-based genomic analysis and explains how it fits into the field of biomedical research. These discussions provide an overview to the actual mechanics of the analyses themselves and offer insights on handling and quality control. Then the book features an important section on the basics of data analysis and clustering methods such as genetic algorithms. Finally, it covers the application of expression profiling in the field of toxicology and addresses the two fundamental types of analysis in detail, with sections dedicated to both mechanistic and predictive studies.
An Introduction to Toxicogenomics consolidates the concepts underlying the field to provide a solid foundation from which to begin your research endeavors.
Contents
1. Fundamentals of Expression Profiling Analysis
Preparation and Utilization of Microarrays
Comparative Studies Using cDNA versus Oligonucleotide Arrays
Quality Control of Expression Profiling Data
An Introduction to Cluster Analysis
2. Expression Profiling and Toxicology: The Advent of Toxicogenomics
Transcriptional Profiling in Toxicology
3. Model Systems in Toxicogenomic Studies
Microarrays in Drug Metabolism and Toxicology: Rat Liver Responses to Prototypical CYP Inducers
Characterization of Hepatocytes and Their Use as a Model System in Toxicogenomics
4. Mechanistic Toxicogenomics
Molecular Signatures of Dioxin Toxicity Toxicogenomic Dissection of the Antioxidant Response
An Overview of Mechanistic Toxicogenomic Studies
5. Predictive Toxicogenomics
Gene Expression Profile Databases in Toxicity Testing
Predictive Toxicogenomics
Unsupervised Hierarchical Clustering of Toxicants
Toxicogenomic Analysis in Clinical Phamacogenomic Studies
6. The Future of Toxicogenomics
The Future of Toxicogenomics